P-164: Comparision The Effect of GNRH Agonist Administration versus Vaginal Progesterone on Serum Progesterone in Luteal Phase in Ovarian Hyperstimulation and Intrauterine Insemination Cycles in Unexplained Infertility

Background: To compare the effect of GnRH agonist administration with vaginal progesterone on serum progesterone in Luteal phase in control ovarian hyper stimulation and intrauterine insemination cycles Materials and Methods: In this clinical trial, 242 infertile patients because of UEI (unexplained inferetility candidate for ovarian stimulation and intrauterine insemination reffering to infertility ward of Mirzakhoochak khan Hospital were recruited.The patients were randomly divided in two groups (A or Progesterone group) and (B or GnRH agonist group).The luteal phase was routinely supplemented in 121 patients (group A) with 400 mg/day/vaginally of natural micronized progesterone starting 1 days after the IUI (intra uterine insemination) for two weeks. In B group (121 patients) a single dose of GnRH agonist (triptorelin 0.1mg) subcutaneously was injected 4 days after IUI. Then serum progesterone level was compared 10 days after IUI in two groups. Results: Totally we evaluated 240 patients with mean age 28.42 ± 4.02 (20-38) years in this trial. The mean serum level progesterone 10 days after IUI in A group was 33.45 ± 18.12ng/ml and in B group was 32.50 ± 23.82 ng/ml and difference between two groups was not significant (p=0.72). also, regarding results of IUI, we found BHCG positive in 20 patients in vaginal group and 19 patients in GnRH group( p=0.86) . Moreover, clinical pregnancy was detected in 15 patients in vaginal progesterone group and in 15 patients in GnRH group(p=NS). Conclusion: We showed GnRH agonist are effective on luteal phase supporting and serum progesterone in patients with unexplained infertility, however GnRH agonists were not more effective than vaginal progesterone.